Rasionalisasi Pemberian Metformin pada Sindrom Ovarium Polikistik

Oleh :

dr. Wendy Damar Aprilano

Metformin merupakan obat sering diberikan untuk menangani sindrom ovarium polikistik atau polycystic ovarian syndrome (PCOS). Namun, mekanisme metformin pada PCOS masih belum dapat dijelaskan sepenuhnya dan terdapat beragam bukti klinis terkait hal ini.

Sindrom ovarium polikistik merupakan salah satu kelainan endokrin yang cukup sering ditemui pada wanita usia reproduktif dengan prevalensi 5–15%. PCOS merupakan salah satu penyebab infertilitas pada wanita, di mana dapat terjadi gangguan ovulasi karena hiperandrogenisme. PCOS biasanya disertai dengan disfungsi ovulasi (oligo/anovulasi), tanda hiperandrogenisme (hirsutisme), dan kista multipel pada ovarium. PCOS juga dapat disertai dengan dislipidemia dan resistensi insulin.[1-3]

BruceBlaus, Wikimedia Commons, 2017.

Dampak jangka panjang dari PCOS sangat luas, meliputi diabetes gestasional, obesitas, diabetes mellitus tipe 2 (DMT2), apnea tidur/sleep apnea, dan gangguan kualitas hidup karena depresi atau ansietas.[4]

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Referensi

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14. HIFERI, PERFITRI, IAUI dan POGI. Konsensus Penanganan Infertilitas. 2013. Diunduh dari http://labcito.co.id/wp-content/uploads/2015/ref/ref/Konsensus_Infertilitas_Revisi_9-1.pdf