Olahraga Bermanfaat dalam Manajemen Fatty Liver

Oleh :

dr. Anastasia Feliciana

Walaupun terkesan sederhana, olahraga bermanfaat dalam pencegahan dan terapi fatty liver. Non-alcoholic Fatty Liver Disease (NAFLD) atau perlemakan hepar merupakan penyebab gangguan hepar kronik terbanyak secara global. NAFLD merupakan sebuah proses yang progresif yang berawal dari simple steatosis, kemudian dapat berkembang menjadi non-alcoholic steatohepatitis (NASH) hingga sirosis hepatis atau bahkan hepatocellular carcinoma (HCC).

Untuk mendiagnosis NAFLD secara definitif, perlu ditemukan adanya steatosis pada >5% hepatosit dari pemeriksaan histologis atau proton density fat fraction; atau >5,6% dengan magnetic resonance spectroscopy. Diagnosis juga baru bisa ditegakkan jika etiologi steatosis lain sudah dieksklusi.[1,2]

Memahami Faktor Risiko Non-alcoholic Fatty Liver Disease (NAFLD)

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):1388–402.
2. Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010 Aug;53(2):372–84.
3. Agrawal S, Duseja AK. Non-alcoholic Fatty Liver Disease: East Versus West. J Clin Exp Hepatol. 2012 Jun;2(2):122–34.
4. McCarthy EM, Rinella ME. The role of diet and nutrient composition in nonalcoholic Fatty liver disease. J Acad Nutr Diet. 2012 Mar;112(3):401–9.
5. Keating SE, George J, Johnson NA. The benefits of exercise for patients with non-alcoholic fatty liver disease. Expert Rev Gastroenterol Hepatol. 2015;9(10):1247–50.
6. van der Windt DJ, Sud V, Zhang H, Tsung A, Huang H. The Effects of Physical Exercise on Fatty Liver Disease. Gene Expr. 2018 18;18(2):89–101.
7. Eckard C, Cole R, Lockwood J, Torres DM, Williams CD, Shaw JC, et al. Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial. Ther Adv Gastroenterol. 2013 Jul;6(4):249–59.
8. Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatol Baltim Md. 2010 Jan;51(1):121–9.
9. Golabi P, Locklear CT, Austin P, Afdhal S, Byrns M, Gerber L, et al. Effectiveness of exercise in hepatic fat mobilization in non-alcoholic fatty liver disease: Systematic review. World J Gastroenterol. 2016 Jul 21;22(27):6318–27.
10. Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatol Baltim Md. 2013 Oct;58(4):1287–95.
11. Keating SE, Hackett DA, Parker HM, O’Connor HT, Gerofi JA, Sainsbury A, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. J Hepatol. 2015 Jul;63(1):174–82.
12. Cigrovski Berkovic M, Bilic-Curcic I, Mrzljak A, Cigrovski V. NAFLD and Physical Exercise: Ready, Steady, Go! Front Nutr. 2021 Oct 5;8:734859.