Peran Linzagolix dalam Penanganan Endometriosis

Oleh :

dr. Cipta Pramana SpOGK

Linzagolix, suatu antagonis gonadotropin-releasing hormone (GnRH), telah dilaporkan efektif untuk penanganan endometriosis. Endometriosis merupakan kasus ginekologi akibat jaringan endometrium yang berada di luar uterus, misalnya di tuba falopii. Endometriosis bisa menimbulkan nyeri pelvis dan bisa menyebabkan infertilitas.[1]

Klinis endometriosis sangat tergantung kadar hormon estrogen, di mana lesi ektopik akan mengalami pertumbuhan, perkembangan, serta perdarahan sehubungan dengan siklus menstruasi. Farmakoterapi endometriosis yang tersedia saat ini memiliki berbagai keterbatasan, sehingga linzagolix diharapkan dapat meningkatkan efikasi dan mengatasi keterbatasan terapi terdahulu.[1,2]

Pendekatan Manajemen Endometriosis Saat Ini

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

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14. Pohl O, Marchand L, Bell D, Gotteland JP. Effects of combined GnRH receptor antagonist linzagolix and hormonal add-back therapy on vaginal bleeding—delayed add-back onset does not improve bleeding pattern. Reprod Sci. 2020;27(4):988–95.
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