Salpingectomy untuk Pencegahan Primer Kanker Ovarium

Oleh :

dr.Giovanny Azalia Gunawan

Salpingectomy diperkirakan dapat menjadi metode pencegahan primer kanker ovarium karena studi-studi sebelumnya menunjukkan bahwa mayoritas kanker ovarium berasal dari bagian ujung tuba fallopi dengan fimbriae. Salpingectomy untuk tujuan pencegahan ini biasanya dilakukan secara oportunistik, yaitu saat operasi lain seperti histerektomi atau sectio caesarea, sesuai diskusi dan pengambilan keputusan bersama pasien.[1]

Kanker ovarium merupakan salah satu penyakit yang memiliki tingkat mortalitas tinggi di bidang ginekologi. Berdasarkan data International Agency for Research on Cancer, kanker ovarium menempati peringkat ke-7 kanker yang paling sering dialami wanita dan peringkat ke-8 sebagai kanker yang paling banyak menyebabkan kematian.[2-6]

Kanker ovarium termasuk kanker yang sulit dideteksi dan cenderung ditemukan dalam kondisi advance, sehingga memiliki prognosis yang kurang baik. Oleh sebab itu, upaya pencegahan yang efektif sangat diperlukan dan masih terus dipelajari, salah satunya berupa salpingectomy oportunistik.[2-6]

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Referensi

1. Kahn RM, Gordhandas S, Godwin K, Stone RL, Worley MJ Jr, et al. Salpingectomy for the Primary Prevention of Ovarian Cancer: A Systematic Review. JAMA Surg. 2023 Nov 1;158(11):1204-1211. doi: 10.1001/jamasurg.2023.4164.
2. Runnebaum, IB. Kather, A. Primary Prevention of Ovarian Cancer by Salpingectomy: That’s One Small Step for A Surgeon, One Giant Leap for Patients. Journal of Cancer Research and Clinical Oncology. 2023;149:6799-6801.
3. Badr, M. Adam, S. Risk-Reducing Salpingectomy and Other Strategies for Prevention of Ovarian and Tubal Carcinoma. Journal of Gynecology & Reproductive Medicine. 2023;7(2):42-53.
4. American College of Obstetricians and Gynecologists. Chohan, L. Richardson, DL. ACOG Committee Opinion no 774: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention. Obstetrics & Gynecology. 2019;133(4):e279-284.
5. Bray F, et al. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2018;68:394-424.
6. Ferlay J, et al. Estimating the Global Cancer Incidence and Mortality in 2018: GLOBOCAN Sources and Methods. Int J Cancer. 2019;144:1941-1953.
7. Hanley GE, et al. Outcomes from Opportunistic Salpingectomy for Ovarian Cancer Prevention. JAMA Network Open. 2022;5(2):e2147343.
8. Venkatesh KK, et al. Cost-Effectiveness of Opportunistic Salpingectomy vs Tubal Ligation at the Time of Cesarean Delivery. American Journal of Obstetrics and Gynecology. 2019;220(1):106-e1.
9. Giannakeas V, et al. Salpingectomy and the Risk of Ovarian Cancer in Ontario. JAMA Network Open. 2023;6(8):e2327198.
10. American College of Obstetricians and Gynecologists. ACOG Committee Opinion no 774 summary: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention. Obstetrics & Gynecology. 2019;133(4):842-843.
11. Runnebaum IB, et al. Opportunistic Salpingectomy for The Primary Prevention of Ovarian Cancer. Dtsch Arztebl Int. 2022;119(49):846-847.
12. Subramaniam A, et al. The Cost-Effectiveness of Opportunistic Salpingectomy versus Standard Tubal Ligation at the Time of Cesarean Delivery for Ovarian Cancer Risk Reduction. Gynecol Oncol. 2019;152(1):127-132.
13. Roeckner JT, et al. Salpingectomy at the Time of Cesarean Delivery: A Systematic Review and Meta-Analysis. Obstetrics & Gynecology. 2020;135(3):550-557.
14. Hanley GE, et al. Extending the Safety Evidence for Opportunistic Salpingectomy in Prevention of Ovarian Cancer: A Cohort Study from British Columbia Canada. Am J Obstet Gynecol. 2018;219(2):172.e1-172.e8
15. Hanley GE, et al. Examining Indicators of Early Menopause Following Opportunistic Salpingectomy: A Cohort Study from British Columbia Canada. Am J Obstet Gynecol. 2020;223(2):221.e1-221.e11.