Hentikan Penggunaan Antibiotik Topikal Pasca Biopsi Kulit

Oleh :

Alexandra Francesca Chandra

Dalam praktik klinis sehari-hari, antibiotik topikal umum diberikan pasca biopsi kulit. Walau demikian, penggunannya dinilai tidak berdasarkan bukti-bukti ilmiah yang ada, melainkan karena kebiasaan dan pengalaman klinisi.[1, 2]

Penggunaan antibiotik topikal bertujuan untuk mengurangi risiko infeksi pada situs pembedahan kulit (dermatological surgical site infection/DSSI). Namun, perlu diingat bahwa penggunaan antibiotik topikal yang berlebihan dapat meningkatkan resistensi antibiotik, dermatitis kontak alergi, mengganggu proses penyembuhan luka, reaksi anafilaksis, serta meningkatkan biaya medis.[1–4]

Antibiotik Topikal yang Umum Digunakan

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Referensi

1. Fathy R, Chu B, James WD, et al. The frequency of topical antibiotic use after biopsy and excision procedures among dermatologists and nondermatologists: 2006 through 2015. J Am Acad Dermatol. 2020 May;82(5):1258-1261. doi: 10.1016/j.jaad.2019.12.060.
2. Akiyama Y, Norimatsu Y, Ohno Y. Prophylactic antimicrobials may not be needed to prevent surgical site infection after skin biopsy: a retrospective study. Antimicrob Resist Infect Control. 2022 Feb 16;11(1):35. doi: 10.1186/s13756-022-01077-z.
3. Fathy R, Chu B, Singh P, et al. Variation in Topical Antibiotics Recommendations in Wound Care Instructions by Non-dermatologists. J Gen Intern Med. 2021 Jan;36(1):238-239. doi: 10.1007/s11606-020-05689-2.
4. Park MS, Kim KD, Eun SJ. Inappropriate Topical Antibiotics Use in Clean Dermatological Procedures in South Korea in 2018: A Nationwide Population-Based Cross-Sectional Study. Korean J Fam Med. 2022 Jul;43(4):231-240. doi: 10.4082/kjfm.21.0139.
5. Anonim. Bacitracin. Drugbank. 2022 https://go.drugbank.com/drugs/DB00626
6. Anonim. Mupirocin. Drugbank. 2022 https://go.drugbank.com/drugs/DB00410
7. Anonim. Polymyxin B. Drugbank. 2022 https://go.drugbank.com/drugs/DB00781
8. Heal C, Lepper P, Banks J. Topical antibiotics to prevent surgical site infection after minor surgery in primary care. Dermatology Practical & Conceptual. 2017;7(3):16-20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661155/
9. Winstanley DA. The Role of Antibiotics in Cutaneous Surgery. Medscape. 2021 https://emedicine.medscape.com/article/1127413-overview#a1
10. Saco M, Howe N, Nathoo R, et al. Topical antibiotic prophylaxis for prevention of surgical wound infections from dermatologic procedures: a systematic review and meta-analysis. J Dermatolog Treat. 2015 Apr;26(2):151-8. doi: 10.3109/09546634.2014.906547.
11. Heal CF, Banks JL, Lepper PD, et al. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. Cochrane Database Syst Rev. 2016;11:CD011426.
12. Akiyama Y, Norimatsu Y, Ohno Y. Prophylactic antimicrobials may not be needed to prevent surgical site infection after skin biopsy: a retrospective study. Antimicrob Resist Infect Control. 2022 Feb 16;11(1):35. doi: 10.1186/s13756-022-01077-z.

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