Perbedaan Natrium Diklofenak dan Kalium Diklofenak

Oleh :

dr.Reni Widyastuti, Sp.FK

Diklofenak diformulasikan dalam bentuk garam natrium yaitu natrium diklofenak, serta garam kalium yaitu kalium diklofenak. Diklofenak digunakan dalam tata laksana nyeri akibat reaksi inflamasi, terutama muskuloskeletal, misalnya rheumatoid arthritis dan osteoarthritis.[1-3]

Diklofenak memiliki aktivitas antiinflamasi, analgesik, dan antipiretik. Diklofenak bekerja dengan menghambat enzim siklooksigenase (COX) dan memiliki potensi yang lebih besar dalam menghambat COX-2 dibandingkan COX-1. Seperti obat antiinflamasi nonsteroid (OAINS) lainnya, efek samping diklofenak meliputi gastrointestinal, kardiovaskular, dan renal yang bersifat dependen dosis.[1-3]

Kalium diklofenak diformulasikan untuk dapat dilepaskan dan diabsorpsi di lambung (immediate release). Sementara itu, natrium diklofenak biasanya beredar dalam sediaan tablet enteric-coated yang dilepaskan di duodenum (delayed-release).[1-3]

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: Evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75(8):859–77.
2. Chuasuwan B, Binjesoh V, Polli JE, Zhang H, Amidon GL, Junginger HE, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: diclofenac sodium and diclofenac potassium. J Pharm Sci. 2009 Apr;98(4):1206-19. doi: 10.1002/jps.21525. PMID: 18752289.
3. Derry S, Wiffen PJ, Moore RA. Single dose oral diclofenac for acute postoperative pain in adults. Cochrane Database Syst Rev. 2015 Jul 7;2015(7):CD004768. doi: 10.1002/14651858.CD004768.pub3. PMID: 26151766; PMCID: PMC6485701.
4. Badan Pengawas Obat dan Makanan. Natrium Diklofenak. Pusat Informasi Obat Nasional, 2015. http://pionas.pom.go.id/monografi/natrium-diklofenak
5. TGA. Australian Product Information; Apo-Diclofenac Enteric Coated Tablets (Diclofenac Sodium). 2023. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-06739-3&d=20210830172310101
6. TGA. Australian Product Information (Diclofenac Potassium). 2023. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-04336-3
7. Bakshi R, Jacobs LD, Lehnert S, Picha B, Reuther J. A double-blind, placebo-controlled trial comparing the analgesic efficacy of two formulations of diclofenac in postoperative dental pain. Curr Ther Res. 1992;52(3):435–42.
8. Siddiqui HK, Anzar W, Taheer TBIN. A double blind placebo controlled clinical trial of diclofenac sodium versus diclofenac potassium on dental extraction patients. 2014;34(2):257–9.
9. Fosbøl EL, Olsen AM, Olesen JB, Andersson C, Kober L, et al. Use of nonsteroidal anti-inflammatory drugs among healthy people and specific cerebrovascular safety. Int J Stroke. 2014 Oct;9(7):943-5. doi: 10.1111/j.1747-4949.2012.00863.x. Epub 2012 Oct 23. PMID: 23088217.
10. Fosbøl EL, Gislason GH, Jacobsen S, Folke F, Hansen ML, et al. Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study. Clin Pharmacol Ther. 2009 Feb;85(2):190-7. doi: 10.1038/clpt.2008.204. Epub 2008 Nov 5. PMID: 18987620.
11. Alfaro RA, Davis DD. Diclofenac. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK557879/
12. US Department of Health and Human Services. Comparative Effectiveness Review, 2011. http://www.ncbi.nlm.nih.gov/books/NBK65646/pdf/Bookshelf_NBK65646.pdf
13. Derry S, et al. Topical NSAIDs for acute musculoskeletal pain in adults (Review). Cochrane Database Syst Rev 2015:CD007402