Perbandingan Breast Conserving Surgery dan Mastektomi bagi Pasien Kanker Payudara

Oleh :

Sunita

Pilihan terapi pembedahan untuk pasien kanker payudara di antaranya mastektomi atau breast conserving surgery (BCS). Pada artikel ini akan dibahas tentang dampak BCS dan mastektomi terhadap kesintasan dan kualitas hidup pasien, serta karakteristik pasien tertentu yang mungkin lebih baik menjalani BCS daripada mastektomi.

BCS merupakan bagian dari breast conserving therapy (BCT) yang bertujuan untuk pengendalian penyakit jangka panjang dengan morbiditas lokal minimum. Sebuah penelitian menunjukkan kesetaraan antara BCT dan mastektomi terkait pengendalian kanker lokoregional pada wanita muda.[1,2]

Pada mayoritas pasien kanker payudara, BCT memberikan hasil pembedahan yang baik dengan tingkat morbiditas psikologis yang lebih rendah daripada mastektomi. Tingkat rekurensi lokal pasca BCS juga semakin menurun seiring dengan perkembangan teknologi pencitraan kanker, perhatian khusus terhadap margin tumor, dan peningkatan efektivitas terapi sistemik.[1,2]

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Houssami N, Macaskill P, Luke Marinovich M, et al. The Association Of Surgical Margins And Local Recurrence In Women With Early-Stage Invasive Breast Cancer Treated With Breast-Conserving Therapy: A Meta-Analysis. Ann Surg Oncol. 2014;21(3):717–30. http://link.springer.com/10.1245/s10434-014-3480-5
2. Cao JQ, Olson RA, Tyldesley SK. Comparison Of Recurrence And Survival Rates After Breast-Conserving Therapy And Mastectomy In Young Women With Breast Cancer. Curr Oncol. 2013;20(6):593–601. https://www.mdpi.com/1718-7729/20/6/1543
3. van Maaren MC, de Munck L, de Bock GH, et al. 10 Year Survival After Breast-Conserving Surgery Plus Radiotherapy Compared With Mastectomy In Early Breast Cancer In The Netherlands: A Population-Based Study. Lancet Oncol. 2016;17(8):1158–70. http://dx.doi.org/10.1016/S1470-2045(16)30067-5
4. Chu QD, Hsieh MC, Lyons JM, et al. 10-Year Survival After Breast-Conserving Surgery Compared With Mastectomy In Louisiana Women With Early-Stage Breast Cancer: A Population-Based Study. J Am Coll Surg. 2021;232(4):607–21. https://doi.org/10.1016/j.jamcollsurg.2020.11.011
5. De Boniface J, Szulkin R, Johansson ALV. Survival After Breast Conservation Vs Mastectomy Adjusted For Comorbidity And Socioeconomic Status: A Swedish National 6-Year Follow-Up Of 48986 Women. JAMA Surg. 2021;156(7):628–37.
6. Tsai HY, Kuo RNC, Chung KP. Quality Of Life Of Breast Cancer Survivors Following Breast-Conserving Therapy Versus Mastectomy: A Multicenter Study In Taiwan. Jpn J Clin Oncol. 2017;47(10):909–18.
7. Ng ET, Ang RZ, Tran BX, et al. Comparing Quality Of Life In Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis. Int J Environ Res Public Health. 2019;16(24):1–11.
8. Zehra S, Doyle F, Barry M, et al. Health-Related Quality Of Life Following Breast Reconstruction Compared To Total Mastectomy And Breast-Conserving Surgery Among Breast Cancer Survivors: A Systematic Review And Meta-Analysis. Vol. 27, Breast Cancer. Springer Japan; 2020. 534–566 p. https://doi.org/10.1007/s12282-020-01076-1