Suplementasi kalsium pada kehamilan ditemukan bermanfaat dalam mencegah terjadinya preeklampsia dan meningkatkan luaran kehamilan. Preeklampsia masih menjadi penyebab utama morbiditas dan mortalitas maternal serta neonatal, yaitu sekitar 14% kematian maternal secara global.[1,2]
Preeklampsia tidak hanya berdampak pada ibu dengan risiko komplikasi seperti eklampsia dan HELLP syndrome yang merupakan bentuk preeklamsia yang lebih parah, dengan gejala klinis berupa hemolisis, peningkatan enzim hati, dan jumlah trombosit yang rendah, tetapi juga meningkatkan risiko bayi lahir prematur, berat badan lahir rendah (BBLR), dan asfiksia. Oleh karena itu, pencegahan preeklampsia menjadi salah satu strategi penting dalam perawatan antenatal.[1–3]
Angka kematian ibu (AKI) di Indonesia pada tahun 2022 dilaporkan mencapai 179 per 100.000 kelahiran hidup, menjadikannya salah satu yang tertinggi di Asia Tenggara. Meskipun AKI telah menurun signifikan dari 450 per 100.000 pada tahun 1990, proporsi kematian akibat perdarahan dan sepsis telah berkurang (dari 48% menjadi 18%), namun kematian yang disebabkan oleh gangguan hipertensi justru meningkat dari 8% menjadi 19%.[4]
(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)
Referensi
1. Xiong J, Chen S, Wang H et al. Global burden of maternal hypertensive disorders (1990–2045): trends, regional disparities, and causal links to occupational exposures. BMC Pregnancy Childbirth 2025;25:641. https://doi.org/10.1186/s12884-025-07766-y.
2. Garovic VD, Dechend R, Easterling T et al. Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association. Hypertension 2022;79. https://doi.org/10.1161/HYP.0000000000000208.
3. ACOG. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020 Jun;135(6):e237-e260. doi: 10.1097/AOG.0000000000003891. PMID: 32443079.
4. Syairaji M, Nurdiati DS, Wiratama BS, et al. Trends and causes of maternal mortality in Indonesia: a systematic review. BMC Pregnancy Childbirth. 2024 Jul 30;24(1):515. doi: 10.1186/s12884-024-06687-6. PMID: 39080562; PMCID: PMC11290122.
5. World Health Organization. WHO recommendation: calcium supplementation during pregnancy for prevention of pre-eclampsia and its complications. Geneva: World Health Organization; 2018.
6. Huang C, Wei K, Lee PMY et al. Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study. BMJ 2022:e072157. https://doi.org/10.1136/bmj-2022-072157.
7. Hofmeyr GJ, Lawrie TA, Atallah ÁN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database of Systematic Reviews 2018;2018. https://doi.org/10.1002/14651858.CD001059.pub5.
8. Korhonen P, Tihtonen K, Isojärvi J et al. Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis. Annals of the New York Academy of Sciences 2022;1510:36–51. https://doi.org/10.1111/nyas.14729.
9. Brown MA, Magee LA, Kenny LC et al. Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension 2018;72:24–43. https://doi.org/10.1161/HYPERTENSIONAHA.117.10803.
10. Oh C, Keats E, Bhutta Z. Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Nutrients 2020;12:491. https://doi.org/10.3390/nu12020491.
11. Jaiswal V, Joshi A, Jha M et al. Association between calcium supplementation and gestational hypertension, and preeclampsia: A Meta-analysis of 26 randomized controlled trials. Current Problems in Cardiology 2024;49:102217. https://doi.org/10.1016/j.cpcardiol.2023.102217.
12. Khaing W, Vallibhakara SA-O, Tantrakul V et al. Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients 2017;9:1141. https://doi.org/10.3390/nu9101141.