Farmakologi Magnesium Sulfat

Oleh :

dr. Queen Sugih Ariyani

Farmakologi magnesium sulfat berkaitan dengan efek vasodilator, antikonvulsan pada eklampsia, dan terminasi torsade pointes. Magnesium memiliki onset yang cepat dan sebagian besar diekskresikan di ginjal.

Farmakodinamik

Farmakodinamik magnesium sebagai kation yang banyak ditemukan pada cairan intraseluler, memainkan peran penting dalam fisiologi dengan bertindak sebagai kofaktor untuk banyak aktivitas enzim, berpartisipasi dalam konduksi saraf, kontraktilitas jantung, dan eksitabilitas otot.[14]

Referensi

1. MIMS. Magnesium Sulfate. [Internet] Available from: https://www.mims.com/indonesia/drug/info/magnesium%20sulfate?mtype=generic
2. FDA. 2016. Magnesium Sulfate. [Internet] Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019316s024lbl.pdf
5. Medscape. Magnesium Sulfate (Rx). [Internet]. Available from: https://reference.medscape.com/drug/mgso4-magnesium-sulfate-344444#10
6. Gilardi E, Marrsialiani D, Nicolo R, Petrucci M, Torelli E, Racco S. Magnesium sulphate in the Emergency Department: an old, new friend. European Review for Medical and Pharmacological Sciences. 2019; 23: 4052-4063. https://www.europeanreview.org/wp/wp-content/uploads/4052-4063.pdf
7. Uptodate. Magnesium sulfate: Drug information. [Internet] Available from: https://www.uptodate.com/contents/magnesium-sulfate-drug-information?topicRef=127535&source=see_link
14. Imaralu JO, Imaralu JO. Evolution of magnesium sulphate for eclampsia. Obstet Gynecol Int J. 2018;9(6):483-486. https://medcraveonline.com/OGIJ/evolution-of-magnesium-sulphate-for-eclampsia.html#ref15
15. Euser AG, Cipolla MJ. Magnesium Sulfate for the Treatment of Eclampsia A Brief Review. Stroke. 2009;40:1169-1175. https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.108.527788
16. Idama TO, Lindow SW. Magnesium sulphate: a review of clinical pharmacology applied to obstetrics. BJOG 2018 https://doi.org/10.1111/j.1471-0528.1998.tb10084.x
17. Cipolla MJ, Kraig RP. Seizures in Women with Preeclampsia: Mechanisms and Management. Fetal Matern Med Rev. 2011;22(2):91-108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119563/
18. Baker WL. Treating arrhythmias with adjunctive magnesium: identifying future research directions, European Heart Journal - Cardiovascular Pharmacotherapy. 2017;3(2):108–117. https://doi.org/10.1093/ehjcvp/pvw028
19. Thomas SH, Behr ER. Pharmacological treatment of acquired QT prolongation and torsades de pointes. Br J Clin Pharmacol. 2016;81(3):420-427. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767204/
20. Drugs.com. 2020. Magnesium sulfate. [Internet] Available from: https://www.drugs.com/ppa/magnesium-sulfate.html

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