Peningkatan Risiko Melanoma Maligna pada Transplantasi Ginjal

Oleh :

dr.SK Sulistyaningrum, Sp.KK, FINSDV, IFAAD

Risiko melanoma meningkat pada resipien transplantasi organ solid, seperti transplantasi ginjal. Adanya melanoma maligna pada resipien transplantasi ginjal akan meningkatkan mortalitas secara signifikan. Namun, bagaimana mekanisme terjadinya dan perjalanan klinis melanoma maligna pada resipien transplantasi sampai saat ini belum diketahui secara pasti.[1-3]

Kejadian Melanoma Maligna Pada Pasien Transplantasi Ginjal

Melanoma maligna merupakan salah satu tipe kanker kulit ganas yang menyerang sel melanosit yang terletak pada lapisan basal epidermis. Mutasi genetik pada jalur Mitogen-Activated Protein Kinase (MAPK) memainkan peran besar dalam munculnya melanoma maligna.

Melanoma maligna pada kaki kiri. Sumber: Will Blake, Wikimedia commons, 2006.

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Referensi

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