Farmakologi Trihexyphenidyl

Oleh :

dr. Andreas Michael Sihombing

Farmakologi trihexyphenidyl berhubungan dengan sifatnya sebagai antagonis reseptor muskarinik, yang mengakibatkan inhibisi pada sistem saraf parasimpatis. Trihexyphenidyl dapat mengurangi gejala tremor pada parkinsonisme dengan memperbaiki gangguan keseimbangan antara jalur neurologis dopaminergik dan kolinergik melalui blokade reseptor muskarinik M1.

Farmakodinamik

Trihexyphenidyl bekerja melalui efek inhibisi terhadap sistem saraf parasimpatis. Trihexyphenidyl merupakan antagonis reseptor muskarinik kompetitif, dengan mekanisme aksi memblok reseptor muskarinik M1.

Referensi

1. U.S. Food & Drug Administration. Drug Approval Package: Trihexyphenidyl Hydrochloride.https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/b6e213da-e882-49d0-9add-7629b35294ce/spl-doc?hl=trihexyphenidyl%20hydrochloride
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