Diagnosis Graft Versus Host Disease

Oleh :

dr. Mia Amelia Mutiara Salikim

Diagnosis graft versus host disease atau GVHD perlu dicurigai pada pasien yang menunjukkan reaksi imun setelah riwayat transplantasi organ, seperti hati atau sumsum tulang, ataupun transfusi darah. Secara garis besar, GVHD dapat dibagi menjadi akut jika timbul dalam 100 hari setelah prosedur transplantasi, ataupun kronik jika timbul setelah 100 hari.[6]

Anamnesis

Graft versus host disease dapat dibedakan menjadi graft versus host disease akut (aGVHD) atau kronik (cGVHD). Kedua kondisi ini dapat menunjukkan tanda dan gejala yang berbeda.

Referensi

1. Ramachandran V, Kolli SS, Strowd LC. Review of Graft-Versus-Host Disease. Dermatol. Clin. 2019;37:569–82.
4. Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol. Blood Marrow Transplant. 2015;21:389-401.e1.
5. Mandanas RA. Graft versus host disease. 2021. https://emedicine.medscape.com/article/429037-overview#a1
6. Martinez-Cibrian N, Zeiser R, Perez-Simon JA. Graft-versus-host disease prophylaxis: Pathophysiology-based review on current approaches and future directions. Blood Rev. 2021;48:100792.
8. Moreno DF, Cid J. Graft-versus-host disease. Med. Clínica Engl. Ed. 2019;152:22–8.
11. Byun HJ, Yang JI, Kim BK, Cho KH. Clinical differentiation of acute cutaneous graft-versus-host disease from drug hypersensitivity reactions. J Am Acad Dermatol. 2011 Oct;65(4):726-732. doi: 10.1016/j.jaad.2010.07.042. Epub 2011 Jun 8. PMID: 21641677.
12. Strong Rodrigues K, Oliveira-Ribeiro C, de Abreu Fiuza Gomes S, Knobler R. Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment. Am J Clin Dermatol. 2018 Feb;19(1):33-50. doi: 10.1007/s40257-017-0306-9. PMID: 28656563; PMCID: PMC5797560.
13. Cices AD, Carneiro C, Majewski S, et al. Differentiating Skin Rash After Stem Cell Transplantation: Graft Versus Host Disease, Cutaneous Reactions to Drugs and Viral Exanthema. Current Dermatology Reports, 2016. 5(1), 12–17. doi:10.1007/s13671-016-0126-9
14. Matsukuma KE, Wei D, Sun K, Ramsamooj R, Chen M. Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol. 2016 Apr;7(Suppl 1):S21-31. doi: 10.3978/j.issn.2078-6891.2015.036. PMID: 27034810; PMCID: PMC4783620.
15. Ghimire S, Weber D, Mavin E, Wang X nong, Dickinson AM, Holler E. Pathophysiology of GvHD and Other HSCT-Related Major Complications. Front. Immunol. 2017;8:79.

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