Diagnosis Middle East Respiratory Syndrome (MERS)

Oleh :

Rainey Ahmad Fajri Putranta

Diagnosis Middle East Respiratory Syndrome (MERS) terutama dicurigai pada pasien dengan riwayat perjalanan/tinggal di daerah endemis MERS dan ditegakkan melalui uji serologi atau Real Time Reverse Transcriptase Polymerase Chain Reaction (rRT-PCR) yang positif. Periode inkubasi MERS-CoV adalah 5 hari.[3,8]

Diagnosis MERS sulit ditentukan hanya dengan anamnesis dan pemeriksaan fisik sebab manifestasi klinis bervariasi dari asimtomatik, gejala infeksi saluran pernapasan akut (ISPA) hingga pneumonia, bahkan dapat terjadi acute respiratory distress syndrome (ARDS), sepsis, dan mortalitas.[16]

Anamnesis

Referensi

2. Kementerian Kesehatan Republik Indonesia. Pedoman Kesiapsiagaan Menghadapi Middle East Respiratory Syndrome-Corona Virus (MERS-CoV). Jakarta: Kementerian Kesehatan. 2017. https://infeksiemerging.kemkes.go.id/download/Buku_Kesiagaan_MERS.pdf
3. Ramadan N, Shaib H. Middle East respiratory syndrome coronavirus (MERS-CoV): A review. Germs. 2019 Mar 1;9(1):35-42. doi: 10.18683/germs.2019.1155. PMID: 31119115; PMCID: PMC6446491.
8. Centers for Disease Control and Prevention. MERS: Clinical Features. 2022. https://www.cdc.gov/coronavirus/mers/clinical-features.html
9. Gompf SG. Middle East Respiratory Syndrome (MERS). 2019. Medscape. https://emedicine.medscape.com/article/2218969-overview#a3
14. Rabaan AA, Al-Ahmed SH, Sah R, Alqumber MA, Haque S, Patel SK, Pathak M, Tiwari R, Yatoo MI, Haq AU, Bilal M, Dhama K, Rodriguez-Morales AJ. MERS-CoV: epidemiology, molecular dynamics, therapeutics, and future challenges. Ann Clin Microbiol Antimicrob. 2021 Jan 18;20(1):8.
15. Azhar EI, Hui DSC, Memish ZA, Drosten C, Zumla A. The Middle East Respiratory Syndrome (MERS). Infect Dis Clin North Am. 2019 Dec;33(4):891-905. doi: 10.1016/j.idc.2019.08.001. PMID: 31668197; PMCID: PMC7127753.
16. World Health Organization. Clinical management of severe acute respiratory infections when novel coronavirus is suspected: what to do and what not to do. 2019. https://apps.who.int/iris/bitstream/handle/10665/178529/WHO_MERS_Clinical_15.1_eng.pdf?sequence=1&isAllowed=y&ua=1
17. Nguyen HH. Influenza. 2021. Medscape. https://emedicine.medscape.com/article/219557-overview
18. Lim WS. Pneumonia—Overview. Reference Module in Biomedical Sciences. 2020:B978-0-12-801238-3.11636-8. doi: 10.1016/B978-0-12-801238-3.11636-8. Epub 2020 May 20. PMCID: PMC7241411.
19. Alzayer Z, Al Nasser Y. Primary Lung Tuberculosis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK567737/
20. Dumitru I. Heart Failure. Medscape. 2022. https://emedicine.medscape.com/article/163062-overview
21.Cha MJ, Chung MJ, Kim K, Lee KS, Kim TJ, Kim TS. Clinical implication of radiographic scores in acute Middle East respiratory syndrome coronavirus pneumonia: Report from a single tertiary-referral center of South Korea. European journal of radiology. 2018 Oct 1;107:196-202.

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